Longitudinal PACC Analyses

Published

December 17, 2024

Significant Results Table

Summary table of all significant results (after fdr correction) from the following longitudinal PACC analyses:

  1. PACC ~ GeneExp
  2. PACC ~ GeneExp*Sex
  3. PACC ~ GeneExp*E4
  4. PACC ~ GeneExp*Sex*E4
  5. PACC ~ GeneExp*Ab
  6. PACC ~ GeneExp*Ab*Sex

Analyses

All models are adjusted for sex, baseline age, years of education, cohort/treatment (A4 Placebo, A4 Treated, LEARN/SF), PACC story version, and cumulative dose. PACC story version and cumulative dose are time varying variables.

PACC ~ Gene x Sex x APOEe4

There is 1 significant gene that survives FDR correction.

Volcano Plot

Summary Table

Significant Results Plots

PACC ~ Gene x Amyloid

There are 6 significant gene that survives FDR correction.

Volcano Plot

Summary Table

Significant Results Plots

Plots of select significant genes

PACC ~ Gene x Sex x Amyloid

There are 118 significant gene that survives FDR correction.

Volcano Plot

Summary Table

Significant Results Plots

Plots of select significant genes